Where can I find the protein concentration?

The protein concentration of each product is listed on the Certificate of Analysis. This value is determined for each individual lot and reflects the actual concentration (mg/mL) of the material you received.

Where can I find the recommended storage conditions?

Storage conditions are listed on both the product datasheet and the Certificate of Analysis. These recommendations are based on internal stability assessments and are intended to maintain protein integrity and activity.

Where can I find reconstitution instructions for lyophilized products?

If your product is supplied lyophilized, recommended reconstitution instructions are provided on the product datasheet. These instructions outline the suggested solvent and handling tips to ensure optimal recovery and stability.

How should I store my product after reconstitution?

Unless otherwise stated on the datasheet or COA, we recommend aliquoting reconstituted material and storing at –80 °C to avoid repeated freeze–thaw cycles, which may impact protein stability and activity.

Alpha 2 Macroglobulin

Name: Alpha 2 Macroglobulin
SKU: 16-16-012013-1MG
Availability: InStock

Alpha-2-macroglobulin (A2M) is a large (725 KDa) plasma glycoprotein found at concentrations of 240 mg/100 ml in men and 290 mg/100 ml in women. This versatile protein functions through a unique "venus-flytrap" mechanism, inhibiting proteases of all catalytic types by forming a tetrameric cage around them.

Beyond protease inhibition, A2M binds and transports cytokines, growth factors, zinc, and damaged proteins. It promotes cell migration, enhances immune function by facilitating antigen processing, and stimulates lymphocyte regeneration in irradiated subjects.

A2M levels increase in nephrotic syndrome, liver cirrhosis, diabetes, and severe burn. Conversely, levels decrease in acute pancreatitis, hyperfibrinolytic states, and septicemia. Research indicates A2M's involvement in Alzheimer's disease pathology through binding and clearing amyloid-beta peptides.

Clinically, A2M shows promise as a therapeutic agent for osteoarthritis, where it inhibits cartilage-degrading enzymes.

Common uses include proteolytic enzyme studies, metal binding studies, biotherapeutic studies.