Where can I find the protein concentration?

The protein concentration of each product is listed on the Certificate of Analysis. This value is determined for each individual lot and reflects the actual concentration (mg/mL) of the material you received.

Where can I find the recommended storage conditions?

Storage conditions are listed on both the product datasheet and the Certificate of Analysis. These recommendations are based on internal stability assessments and are intended to maintain protein integrity and activity.

What should I do if my product arrives warm, partially thawed, or damaged?

Please contact Athens Bioscience with your order number and lot number. Our technical support team will assist you promptly.

Where can I find the final buffer composition?

The final buffer formulation is provided on the Certificate of Analysis. This includes buffer components, pH, and whether the product was supplied as a liquid or lyophilized powder.

Inter Alpha Inhibitor Proteins

Name: Inter Alpha Inhibitor Proteins
SKU: 16-16-090109-25UG
Availability: InStock

Product Description

Role of protein in biology

Inter Alpha Inhibitor Proteins (IaIp) are a family of serine protease inhibitors present in human plasma, including Inter Alpha Trypsin Inhibitor (IaI, 225 kDa) and Pre Alpha Inhibitor (Pal, 125 kDa), with a combined concentration of about 50 mg/100 mL. Their inhibitory function is primarily mediated by bikunin, a conserved light chain with Kunitz-type domains that neutralizes proteases and modulates inflammation. IaIp play a critical role in the regulation of extracellular matrix stability by interacting with hyaluronic acid, which is essential for tissue integrity and repair. During acute inflammation, IaI acts as a negative acute-phase protein while Pal serves as a positive acute-phase protein, reflecting their dynamic involvement in immune responses.

Common research uses

Clinically, IaIp have emerged as biomarkers and potential therapies for conditions such as sepsis, metastatic disease, stroke, and complement system disorders due to their ability to neutralize proinflammatory cytokines, inhibit complement activation, and protect against histone-induced cytotoxicity and tissue damage 2. Additionally, specific IaIp components are being investigated as biomarkers for autoimmune diseases like myasthenia gravis.

Common uses include immune system research, enzymatic and inhibition assays, therapeutics research, IVD Assay standards, calibrators and controls.