Where can I find the protein concentration?

The protein concentration of each product is listed on the Certificate of Analysis. This value is determined for each individual lot and reflects the actual concentration (mg/mL) of the material you received.

Where can I find the specific activity of an enzyme or inhibitor?

For enzymatic products and inhibitors with published activity specifications, specific activity is reported on the Certificate of Analysis. This information is lot-specific and is generated using our validated internal activity assays. If not stated on your CoA, please contact Athens' Technical Support.

Where can I find reconstitution instructions for lyophilized products?

If your product is supplied lyophilized, recommended reconstitution instructions are provided on the product datasheet. These instructions outline the suggested solvent and handling tips to ensure optimal recovery and stability.

How should I store my product after reconstitution?

Unless otherwise stated on the datasheet or COA, we recommend aliquoting reconstituted material and storing at –80 °C to avoid repeated freeze–thaw cycles, which may impact protein stability and activity.

Alpha 1 Antichymotrypsin

Name: Alpha 1 Antichymotrypsin
SKU: 16-16-012400-100UG
Availability: InStock

A1X, ACT, AACT, SerpinA3

A SERPIN which plays a critical role in inhibiting serine protease activity to protect tissue from enzymatic degradation, particularly in the lower respiratory tract.

Purity: ≥95% (SDS-PAGE)

Source: Human Plasma

Molecular Weight: 64 kDa

Form: Lyophilized

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Product Description

Role of protein in biology

Alpha 1-antichymotrypsin (ACT) is an acute-phase plasma glycoprotein encoded by the SERPINA3 gene, primarily produced in the liver. As a member of the serpin superfamily, ACT functions by inhibiting chymotrypsin-like serine proteases, including neutrophil cathepsin G and mast cell chymase. This protective mechanism prevents tissue damage from proteolytic enzymes, particularly in the lower respiratory tract.

Common research uses

ACT is significantly involved in Alzheimer's disease pathology, where it's overexpressed in astrocytes surrounding amyloid plaques, enhancing amyloid-beta fibrillization and inducing tau hyperphosphorylation. It's also elevated in rheumatoid arthritis, Crohn's disease, ulcerative colitis, and following burn injuries.

Clinically, the PSA-ACT complex serves as a valuable biomarker for prostate cancer, indicating tumor mass and clinical staging.

Common uses include Proteolytic enzyme studies, IVD standards, calibrator, and control.