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The major plasma lipoprotein responsible for the transport of cholesterol from the liver to peripheral tissues. Elevated levels correlate to heart disease risk.
Low-density lipoprotein (LDL) is a major plasma lipoprotein, with normal fasting concentrations ranging from 2.0 to 3.5 g/L, and accounts for about 50% of the total lipoprotein mass in the bloodstream. LDL’s primary role is to transport cholesterol and cholesteryl esters from the liver to peripheral tissues, where cholesterol is essential for membrane structure and steroid hormone synthesis. The protein component, apolipoprotein B-100, enables LDL to bind to LDL receptors on cell surfaces, facilitating cholesterol uptake via receptor-mediated endocytosis.
Elevated LDL levels are a well-established risk factor for atherosclerosis and coronary heart disease, as excess LDL cholesterol can accumulate in arterial walls, triggering inflammation and plaque formation. LDL is also implicated in other conditions such as stroke and peripheral artery disease. Clinically, LDL measurement is central to cardiovascular risk assessment and guides therapeutic interventions. In research, LDL is used to study lipid metabolism, receptor interactions, and the development of lipid-lowering drugs.
Common uses include IVD Assay standards, calibrators and controls, therapeutics research, cardiovascular research, cell based assays, cell culture media supplement.
Not a hazardous substance or mixture.
12 - Non Combustible Liquids
The major plasma lipoprotein responsible for the transport of cholesterol from the liver to peripheral tissues. Elevated levels correlate to heart disease risk.
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