Chylomicrons are enterocyte-derived triglyceride-rich lipoproteins that transport dietary lipids from the intestine to peripheral tissues and the liver. These particles (~75–1,200 nm diameter) consist of a hydrophobic core of triglycerides (85–92%) and cholesterol esters, surrounded by a phospholipid monolayer containing apolipoproteins. ApoB-48, synthesized exclusively in the intestine through mRNA editing of the APOB gene, serves as the structural scaffold for chylomicron assembly. During circulation, chylomicrons acquire apoE and apoC-II from HDL, with the latter activating lipoprotein lipase (LPL) to hydrolyze triglycerides into free fatty acids for tissue uptake. Post-lipolysis remnants, enriched in cholesterol and apoE, are cleared by hepatic receptors (LDL-R, LRP1).