Where can I find the protein concentration?

The protein concentration of each product is listed on the Certificate of Analysis. This value is determined for each individual lot and reflects the actual concentration (mg/mL) of the material you received.

Where can I find the recommended storage conditions?

Storage conditions are listed on both the product datasheet and the Certificate of Analysis. These recommendations are based on internal stability assessments and are intended to maintain protein integrity and activity.

Where can I find reconstitution instructions for lyophilized products?

If your product is supplied lyophilized, recommended reconstitution instructions are provided on the product datasheet. These instructions outline the suggested solvent and handling tips to ensure optimal recovery and stability.

How should I store my product after reconstitution?

Unless otherwise stated on the datasheet or COA, we recommend aliquoting reconstituted material and storing at –80 °C to avoid repeated freeze–thaw cycles, which may impact protein stability and activity.

Immunoglobulin G, Mouse

Name: Immunoglobulin G, Mouse
SKU: 16-16-090707-mouse-1MG
Availability: InStock

IgG, Immunoglobulin Gamma

IgG is the predominant circulating immunoglobulin in plasma with four subclasses, each with distinct functions. IgG is one of the most utlized proteins in biological research.

Purity: ≥95% (SDS-PAGE)

Source: Mouse Plasma

Molecular Weight: 150 kDa

Form: Lyophilized

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Product Description

Role of protein in biology

Immunoglobulin G (IgG), the most abundant plasma antibody (8–18 mg/mL), comprises four subclasses (IgG1–4) with distinct effector functions mediated by structural variations in their Fc regions. IgG neutralizes pathogens through Fab-mediated antigen binding and Fc-dependent mechanisms, including complement activation (via C1q binding to IgG1/IgG3) and antibody-dependent cellular cytotoxicity (ADCC) through FcγRIIIa engagement on natural killer cells. IgG’s extended half-life (21 days) arises from pH-dependent FcRn recycling, which also facilitates placental transfer, conferring neonatal immunity.

Common research uses

IgG is an important protein in the life sciences. Plasma derived IgG is widely used as a therapuetic to treat diseases such as Primary Immunodeficiencies. Engineered monoclonal IgGs therapies are widely used in the treatment of cancers and autoimmune diseases. IgG is also used in flow cytometry as an Fc receptor blocking agent.