Where can I find the protein concentration?

The protein concentration of each product is listed on the Certificate of Analysis. This value is determined for each individual lot and reflects the actual concentration (mg/mL) of the material you received.

Where can I find the recommended storage conditions?

Storage conditions are listed on both the product datasheet and the Certificate of Analysis. These recommendations are based on internal stability assessments and are intended to maintain protein integrity and activity.

Where can I find reconstitution instructions for lyophilized products?

If your product is supplied lyophilized, recommended reconstitution instructions are provided on the product datasheet. These instructions outline the suggested solvent and handling tips to ensure optimal recovery and stability.

How should I store my product after reconstitution?

Unless otherwise stated on the datasheet or COA, we recommend aliquoting reconstituted material and storing at –80 °C to avoid repeated freeze–thaw cycles, which may impact protein stability and activity.

Immunoglobulin G

Name: Immunoglobulin G
SKU: 16-16-090707-10MG
Availability: InStock

IgG, Immunoglobulin Gamma

IgG is the predominant circulating immunoglobulin in plasma with four subclasses, each with distinct functions. IgG is one of the most utilized proteins in biological research.

Purity: ≥95% (SDS-PAGE)

Source: Human Plasma

Molecular Weight: 150 kDa

Form: Lyophilized

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Product Description

Role of protein in biology

Immunoglobulin G (IgG), the most abundant plasma antibody (8–18 mg/mL), comprises four subclasses (IgG1–4) with distinct effector functions mediated by structural variations in their Fc regions. IgG neutralizes pathogens through Fab-mediated antigen binding and Fc-dependent mechanisms, including complement activation (via C1q binding to IgG1/IgG3) and antibody-dependent cellular cytotoxicity (ADCC) through FcγRIIIa engagement on natural killer cells. IgG’s extended half-life (21 days) arises from pH-dependent FcRn recycling, which also facilitates placental transfer, conferring neonatal immunity.

Common research uses

Clinically, IgG deficiencies manifest as recurrent sinopulmonary infections: selective IgG subclass deficiencies (e.g., IgG2 impairing antipolysaccharide responses), while agammaglobulinemia features near-absent IgG (<200 mg/dL). Autoimmune disorders exhibit subclass-specific involvement-IgG4 drives MuSK myasthenia gravis through functional blockade, whereas IgG1/IgG3 mediate tissue damage in pemphigus via complement activation. Therapeutically, intravenous IgG (IVIG) at 2 g/kg modulates immunity in Guillain-Barré syndrome by Fc receptor saturation and anti-idiotypic effects. Diagnostic applications leverage IgG’s specificity in serological assays, with subclass profiling guiding immunodeficiency management.

Common uses include ELISA standards, IVD Assay standards, calibrators and controls, therapeutics research, immune system research, flow cytometry assays.