Where can I find the protein concentration?

The protein concentration of each product is listed on the Certificate of Analysis. This value is determined for each individual lot and reflects the actual concentration (mg/mL) of the material you received.

Where can I find the recommended storage conditions?

Storage conditions are listed on both the product datasheet and the Certificate of Analysis. These recommendations are based on internal stability assessments and are intended to maintain protein integrity and activity.

Where can I find reconstitution instructions for lyophilized products?

If your product is supplied lyophilized, recommended reconstitution instructions are provided on the product datasheet. These instructions outline the suggested solvent and handling tips to ensure optimal recovery and stability.

How should I store my product after reconstitution?

Unless otherwise stated on the datasheet or COA, we recommend aliquoting reconstituted material and storing at –80 °C to avoid repeated freeze–thaw cycles, which may impact protein stability and activity.

Haptoglobin, Mixed Type

Name: Haptoglobin, Mixed Type
SKU: 16-16-080116-1MG
Availability: InStock

Zonulin, HPT, HP, BP, HP2ALPHA2, HPA1S

An acute phase protein with three phenotypes in the human population. Haptoglobin binds free hemoglobin preventing iron loss and oxidative tissue damage.

Purity: ≥95% (SDS-PAGE)

Source: Human Plasma

Molecular Weight: Hp 1-1: 86 kDa; Hp 2-1: 200 kDa; Hp 2-2: 400 kDa

Form: Lyophilized

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Product Description

Role of protein in biology

Haptoglobin is a major acute-phase plasma glycoprotein present at concentrations of 100–300 mg/dL, primarily synthesized in the liver. Its central function is to bind free hemoglobin released during red blood cell breakdown, thereby preventing iron loss through the kidneys and reducing hemoglobin-driven oxidative tissue damage. This hemoglobin–haptoglobin complex is rapidly cleared by macrophages via the CD163 receptor, facilitating iron recycling and modulating antioxidant and anti-inflammatory pathways. Haptoglobin also influences immune responses, interacting with neutrophils, lymphocytes, and dendritic cells to regulate inflammation and adaptive immunity.

Common research uses

Humans exhibit three main haptoglobin phenotypes-Hp 1-1, Hp 2-1, and Hp 2-2-arising from genetic polymorphisms. Hp 1-1 demonstrates the highest hemoglobin-binding and antioxidant efficiency, while Hp 2-2 is least effective, which may explain its association with increased risk and severity of conditions such as cardiovascular disease, diabetes, and epilepsy. Notably, the Hp 2-2 phenotype is linked to poorer outcomes in coronary artery disease and more frequent epilepsy attacks, likely due to reduced antioxidant protection in neural tissues. Clinically, haptoglobin serves as a sensitive biomarker for hemolytic anemia, liver function, and as a potential prognostic marker in cancer and inflammatory diseases. Therapeutically, recombinant haptoglobin is being explored for treating hemolysis-related complications and as a neuroprotective agent following subarachnoid hemorrhage.

Common uses include metabolic studies, IVD Assay standards, calibrators and controls, therapeutics research, cardiovascular research, mass spectrometry, oxidative stress research.