Where can I find the protein concentration?

The protein concentration of each product is listed on the Certificate of Analysis. This value is determined for each individual lot and reflects the actual concentration (mg/mL) of the material you received.

Where can I find the recommended storage conditions?

Storage conditions are listed on both the product datasheet and the Certificate of Analysis. These recommendations are based on internal stability assessments and are intended to maintain protein integrity and activity.

Where can I find reconstitution instructions for lyophilized products?

If your product is supplied lyophilized, recommended reconstitution instructions are provided on the product datasheet. These instructions outline the suggested solvent and handling tips to ensure optimal recovery and stability.

How should I store my product after reconstitution?

Unless otherwise stated on the datasheet or COA, we recommend aliquoting reconstituted material and storing at –80 °C to avoid repeated freeze–thaw cycles, which may impact protein stability and activity.

Leucine-rich Alpha 2 Glycoprotein-1

Name: Leucine-rich Alpha 2 Glycoprotein-1
SKU: 16-16-121807-50UG
Availability: InStock

LRG1, LRG

An acute phase protein which rises during bacterial infections and inflammation. It modulates immune responses as an upstream regulator of the TGF-β signaling pathway.

Purity: ≥95% (SDS-PAGE)

Source: Human Plasma

Molecular Weight: 50 kDa

Form: Lyophilized

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Product Description

Role of protein in biology

Leucine-rich alpha-2 glycoprotein 1 (LRG1) is a multifunctional plasma protein present at concentrations of 21–50 μg/mL in healthy individuals. As an acute-phase protein, LRG1 levels rise significantly during bacterial infections and various inflammatory conditions, but its regulation is independent of traditional markers like C-reactive protein (CRP). LRG1 plays a key role in modulating immune and vascular responses, acting as an upstream regulator of the TGF-β signaling pathway and promoting angiogenesis by influencing endothelial cell behavior. It binds cytochrome c, a molecule involved in apoptosis, thereby potentially supporting cell survival during tissue injury and inflammation.

Common research uses

Elevated LRG1 is recognized as a biomarker for multiple cancers-including non-small cell lung, colorectal, pancreatic, and ovarian cancer-where it correlates with disease progression and prognosis. Beyond oncology, LRG1 is implicated in cardiovascular, renal, autoimmune, and neurodegenerative diseases, such as Parkinson’s disease, and is being explored as a diagnostic and therapeutic target due to its roles in inflammation, vascular dysfunction, and tissue remodeling.

Common uses include IVD Assay standards, calibrators and controls, therapeutics research, immune system research.