+3
Loading...
Complement C5, a glycoprotein composed of α (115 kDa) and β (75 kDa) chains, serves as the linchpin of complement-mediated immunity. Cleaved by C5 convertases into C5a (potent anaphylatoxin) and C5b (initiator of membrane attack complex/MAC), it bridges inflammatory signaling and pathogen lysis. C5a drives chemotaxis, leukocyte activation, and vascular permeability via C5aR1/C5aR2 receptors, while C5b-9 (MAC) induces microbial cytolysis.
C5 deficiency increases susceptibility to recurrent pyogenic infections (e.g., Neisseria) and Leiner’s disease. Elevated C5a correlates with rheumatoid arthritis, Guillain-Barré syndrome, and chemotherapy-induced neuropathy.
Common uses include complement and immune system research, IVD assay standards, calibrators and controls.
Not a hazardous substance or mixture.
12 - Non Combustible Liquids
