+3
Loading...
Ceruloplasmin (Cp), a ferroxidase belonging to the multi-copper oxidase family, serves as the primary copper transport protein in plasma, binding 95% of circulating copper. Beyond copper homeostasis, Cp exhibits critical roles in iron metabolism by oxidizing Fe²⁺ to Fe³⁺ for transferrin-mediated transport, lipid regulation, and antioxidant defense. As an acute-phase reactant, Cp levels rise during inflammation, infection, trauma, and pregnancy due to estrogen-induced hepatic synthesis.
Reduced Cp levels hallmark Wilson’s disease (impaired copper ATPase) and aceruloplasminemia (genetic ferroxidase loss), causing copper deposition in tissues and neurodegenerative iron accumulation, respectively.
Elevated Cp correlates with rheumatoid arthritis severity (as an acute-phase marker), liver cirrhosis progression, and cardiovascular risk via prooxidant LDL oxidation in atherosclerotic plaques. Cp also predicts tumor aggressiveness in breast, lung, and ovarian cancers.
Cp serves as a biomarker for Wilson’s disease screening and preeclampsia monitoring. In chronic hepatitis B, Cp combined with GGT forms a non-invasive model for liver fibrosis staging. Therapeutic strategies targeting Cp’s ferroxidase activity or copper-binding sites are under exploration for neurodegenerative and oncological disorders.
Common uses include metabolic studies, copper transport studies, IVD Assay standards, calibrators and controls, immune system research.
Not a hazardous substance or mixture.
11 - Combustible Solids
