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Angiotensinogen (AGT), a glycoprotein circulating at 2.8–7.1 mg/100 mL in plasma, serves as the precursor for all angiotensin peptides in the renin-angiotensin system (RAS), a critical regulator of blood pressure, fluid balance, and electrolyte homeostasis. Primarily synthesized by the liver, AGT is also produced in the brain, kidneys, adipose tissue, and arterial walls.
AGT’s structural dynamics involve redox-sensitive disulfide bonds (Cys18-Cys138) and glycosylation, which modulate renin’s access to its cleavage site. As a non-inhibitory SERPIN, AGT lacks protease-inhibitory activity but undergoes conformational changes upon renin binding, releasing angiotensin I (AngI). Subsequent processing yields vasoactive peptides (AngII, Ang1-7, etc.), influencing vascular tone, inflammation, and fibrosis. During pregnancy, total AGT levels surge fourfold, while AGT increases 20-fold, becoming predominant in amniotic fluid (80%).
Common uses include ELISA Standards, Hemostasis studies, and cardiovascular research.
Not a hazardous substance or mixture.
11 - Combustible Solids
